Select publications & recent preprints:

(*Equal contribution, **Corresponding author)

PREVIEW

Screen Shot 2024-03-01 at 8.45.23 PM.png

Screen Shot 2023-11-16 at 6.52.54 PM.png

Screen Shot 2023-11-16 at 6.55.53 PM.png

Screen Shot 2023-11-16 at 6.49.26 PM.png

Screen Shot 2023-11-16 at 6.53.33 PM.png

Screen Shot 2023-11-16 at 6.51.39 PM.png

Screen Shot 2023-11-16 at 6.55.16 PM.png

Screen Shot 2023-11-16 at 6.54.44 PM.png

Screen Shot 2023-11-16 at 6.52.14 PM.png

Screen Shot 2023-11-16 at 6.58.12 PM.png

Screen Shot 2023-11-16 at 6.50.00 PM.png

Screen Shot 2023-11-16 at 6.56.29 PM.png

Screen Shot 2023-11-16 at 6.50.53 PM.png

Screen Shot 2023-11-16 at 6.57.36 PM.png

Screen Shot 2023-11-16 at 6.54.10 PM.png

Shokrollahi, M.*, Stanic, M.*, Hundal, A.*, Chan, J.N.Y., Urman D., Jordan C.A., Hakem, A., Espin, R., Hao, J., Krishnan, R., Maass, P.G., Dickson, B.C., Hande, M.P., Pujana, M.A., Hakem, R.** and Mekhail, K.** (2024) DNA double-strand break-capturing nuclear envelope tubules drive DNA repair. Nature Struct. Mol. Biol. doi: 10.1038/s41594-024-01286-7. nature.com

Hundal, A.*, Urman, D.*, Stanic, M., Hakem, R.** and Mekhail, K.** (2024) Protocol for machine-learning-based 3D image analysis of nuclear envelope tubules in cultured cells. STAR Prot. doi: 10.1016/j.xpro.2024.103214. cell.com

Yerlici, V.T., Astori, A., Kejiou, N.S., Jordan, C.A., Khosraviani, N., Chan, J.N.Y., Hakem, R., Raught, B., Palazzo, A.F., and Mekhail, K.** (2024) SARS-CoV-2 targets ribosomal RNA biogenesis. Cell Reports 43(3):113891:1-16 cell.com

Khosraviani, N., Yerlici, V.T., St-Germain, J., Hou, Y.Y., Cao, S.B., Ghali, C., Krishnan, R., Hakem, R., Raught, B., and Mekhail, K.** Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis. bioRxiv 2023.12.10.570972; doi: https://doi.org/10.1101/2023.12.10.570972

Liu, Y., Iqbal, A., Li, W., Ni, Z., Wang, Y., Ramprasad, J., Abraham, K.J., Zhang, M., Zhao, D.Y., Qin, S., Loppnau, P., Jiang, H., Guo, X., Brown, P.J., Zhen, X., Xu, G., Mekhail, K., Ji, X., Bedford, M.T., Greenblatt, J.F., and Min, J.** (2022) A small molecule antagonist of SMN disrupts the interaction between SMN and RNAPII. Nature Communications 13:5453:1-12. nature.com

Stanic, M., and Mekhail, K.** (2022) Integration of DNA damage responses with dynamic spatial genome organization. Trends in Genetics 38(3):290-304. cell.com

Patel, P.S., Abraham, K.J.*, Guturi, K.K.N.*, Halaby, M-J., Khan, Z., Palomero, L., Ho, B., Duan, S., St-Germain, J., Algouneh, A., Mateo, F., El Ghamrasni, S., Barbour, H., Barnes, D.R., Beesley, J., Sanchez, O., Berman, H.K., Brown, G.W., Affar, E.B., Chenevix-Trench, G., Antoniou, A.C., Arrowsmith, C.H., Raught, B., Pujana, M.A., Mekhail, K., Hakem, A.**, and Hakem, R.** (2021) RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors. Journal of Clinical Investigation 131(3):e140105. jci.com

Shokrollahi, M., and Mekhail, K.** (2021) Interphase microtubules in nuclear organization and genome maintenance. Trends in Cell Biology. cell.com

Abraham, K.J.*, Khosraviani, N.*, Chan, J.N., Gorthi, A., Samman, A., Zhao, D.Y., Wang, M., Bokros, M., Vidya, E., Ostrowski, L.A., Oshidari, R., Pietrobon, V., Patel, P., Algouneh, A., Singhania, R., Liu, Y., Yerlici, V.T., De Carvalho, D.D., Ohh, M., Dickson, B.C., Hakem, R., Greenblatt, J.F., Lee, S., Bishop, A.J.R., and Mekhail, K**. (2020) Nucleolar RNA polymerase II drives ribosome biogenesis. Nature 585:298-302 doi: 10.1038/s41586-020-2497-0. nature.com

Oshidari, R., Huang, R., Medghalchi, M., Tse, E.Y.W., Ashgriz, N., Lee, H.O., Wyatt, H., and Mekhail, K.** (2020) DNA repair by Rad52 liquid droplets. Nature Communications 11:695:1-8 doi: 10.1038/s41467-020-14546-z. nature.com

Oshidari, R., Mekhail, K.**, and Seeber, A.** (2020) Mobility and repair of damaged DNA: random or directed? Trends in Cell Biology 30:2:144-156 cell.com

Todd, L.A., Hall, A.C., Pietrobon, V., Chan, J.N., Laflamme, G., and Mekhail, K.** (2020) RNA-cDNA hybrids mediate transposition via different mechanisms. Scientific Reports 10:16034:1-12. nature.com

Laflamme, G., and Mekhail, K.** (2020) Biomolecular condensates as arbiters of biochemical reactions inside the nucleus. Communications Biology 3:773:1-8 nature.com

Hall, A.*, Ostrowski, L.A.*, and Mekhail, K.** (2019) Phase separation as a melting pot for DNA repeats. Trends in Genetics 35:8:589-600 cell.com

Ostrowski, L.A.*, Hall, A.C.*, Szafranski, K.J., Oshidari, R., Abraham, K.J., Chan, J.N., Krustev, C., Zhang, K., Wang, A., Liu, Y., Guo, R. and Mekhail, K.** (2018) Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats. Communications Biology 1:187:1-17 doi: 10.1038/s42003-018-0187-3. nature.com

Oshidari, R., Strecker, J., Chung, D.K., Abraham, K.J., Chan, J.N., Damaren, C.J. and Mekhail, K.** (2018) Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair. Nature Communications 9:2567:1-11 doi: 10.1038/s41467-018-05009-7. nature.com

Abraham, K.J., Chan, J.N., Salvi, J., Ho, B., Hall, A., Vidya, E., Guo, R., Killackey, S.A., Liu, N., Lee, J.E., Brown, G.W., and Mekhail, K.** (2016) Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids. Nucleic Acids Research 44(18):8870-8884 doi: 10.1093/nar/gkw752 OxfordAcademic.com

Chung, K.C., Chan, J.N.*, Strecker, J.*, Zhang, W., Ebrahimi-Ardebili, S., Lu, T., Abraham, K.J., Durocher, D. and Mekhail, K.** (2015) Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process. Nature Communications 6:7742:1-13 doi: 10.1038/ncomms8742. nature.com

Salvi, J.S., Chan, J.N.Y., Szafranski, K, Liu, T.T., Wu, J.D., Olsen, J.B., Khanam, N., Poon, B.P.K., Emili, A., and Mekhail, K.** (2014) Roles for Pbp1 and caloric restriction in genome and lifespan maintenance via suppression of RNA-DNA hybrids. Developmental Cell 30(2):177-191. [cover article]. cell.com

Chan, J.N.Y.*, Poon, B.P.K.*, Salvi, J.*, Olsen, J.B., Emili, A., and Mekhail, K.** (2011) Perinuclear cohibin complexes maintain replicative lifespan via roles at distinct silent chromatin domains. Developmental Cell 20:867-879. cell.com

Mekhail, K.**, and Moazed D.** (2010) The nuclear envelope in genome organization, expression, and stability. Nature Reviews Molecular Cell Biology 11:317-328. nature.com

Tomson, B. N., Rahal, R., Reiser, V., Monje-Casas, F., Mekhail, K., Moazed, D., and Amon, A. (2009) Regulation of Spo12 phosphorylation and its essential role in the FEAR network. Current Biology 19:449-460. cell.com

Mekhail, K., Seebacher, J., Gygi, S. P., and Moazed, D. (2008) Role for perinuclear chromosome tethering in the maintenance of genome stability. Nature 456:667-670. nature.com

Click here for a full list of our publications.

PUBLICATIONS

Select publications & recent preprints: